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EpiGro1000 - Swinney Nutrition
EpiGro1000 - Swinney Nutrition
EpiGro1000 - Swinney Nutrition

EpiGro1000 - Swinney Nutrition

$ 119.99

Brief Summary of Epi-Gro1000's Ingredients

Epicatechin:

Epi-Gro1000 is the premier Epicatechin / Catechin supplement containing 1000 mg of Epicatechin per 2 capsules serving and 60 servings per bottle (60,000 mg of Epicatechin per bottle), which more than triples the amount of Epicatechin in the other leading brands. 

Green Tea Extract (50% EGCG) and Huperzine A:

Additionally, 400 mg of Green Tea Extract standardized to 98% Polyphenols and 50% EGCG providing 200 mg EGCG Catechins to each 2 capsules serving with a synergistic 200 mcg of Huperzine A.

The two daily servings of Epi-Gro1000 provides: 

  • 2000 mg of (-)-Epicatechin(Epicatechin Extract Cocoa Beans)
  • 800 mg of Green Tea Extract
    • (50% EGCG = 400 mg of EGCG Catechins)
  • 400 mcg Huperzine A

 

Ingredient Dosing Questions

Question:

If the industry standard is ~ 300 mg to 600 mg of Epicatechin per day and other companies only use ~ 300 mg of Epicatechin per serving, why did Swinney Nutrition decide to use such a high dose 2000 mg per day of Epicatechin (1000 mg x 60 servings)?

 

Brief Answer (Detailed Reference Based Answer Below):

Swinney Nutrition’s Epi-Gro1000 uses a high dose of Epicatechin (2000 mg Epicatechin per day) because that is the dose we associated with the most consistent body recomposition results.  

Question:

Why would an individual supplement with Epi-Gro1000?

Brief Answers (Detailed Reference Based Answer Below):

The shortest answer:

Body Recomposition.

The slightly longer answer:

Generally, Epi-Gro1000 can be referred to as a natural-anabolic.  The main ingredients may be recognized as natural because they have been found in cocoa, teas, berries, apples, and grape seeds.  Thus, they may be viewed as anabolic because clinical studies have associated them with the molecular processes related to skeletal muscle growth.  Therefore, If an individual is looking for a non-hormonal supplement to enhance muscle growth and fat loss, then Epi-Gro1000 should be at the top of their list.

Brief Epi-Gro1000 Summary 

(Detailed Reference Based Summary Below):

Overall, Epi-Gro1000 has been formulated to increase muscle and reduce fat through the mechanisms of reducing myostatin and somatostatin inhibition.

Epigro1000 also increases insulin sensitivity, and nutrient partitioning, as well. The favorable changes in body composition will also be accompanied by improvements in muscle contraction, growth and differentiation.

Suggested Use

As a dietary supplement, take 2 capsules (1 serving), with or without food, twice per day and separated by 4 to 6 hours. 

Do not exceed 6 capsules in a 24-hour period unless directed otherwise by a healthcare professional.

Epi-Gro1000

Detailed Scientific and Reference Based Information

Question:

How do the ingredients in Epi-Gro1000 enhance muscle growth and fat loss?

 

Answer:

Since humans are complex dynamic systems with different homeostatic environments and adaptive constraints, isolating the exact reason Epi-Gro1000 may produce positive body recomposition effects across the general population is nearly impossible.  But we can identify the potential mechanisms associated with Epi-Gro1000’s ingredients and body recomposition in the clinical literature. 

 

If an individual wants to understand the potential mechanisms associated with a supplement, then they must begin by developing a solid base of foundational knowledge for each ingredient.  While Epi-Gro1000’s main ingredients (Epicatechin and EGCG Catechins) are generally classified as polyphenols, they are specifically classified as flavanols in the polyphenol subgroup called flavonoids.  Therefore, it may be advantageous to briefly discuss each category and highlight some of the relevant clinical literature regarding the potential health promotion and human performance benefits.

 

Polyphenols are naturally occurring secondary metabolites found in fruits, vegetables, and herbs that may have health promotion and human performance benefits. [1.]  Various epidemiological studies on animals and humans have demonstrated that polyphenols have antioxidant and anti-inflammatory qualities that could provide a positive effect against inflammation [2.], neurodegenerative diseases [2.] [3.] [4.] [5.] [6.] [7.] [8.] [9.] [10.] [11.] , cancer [2.] [11.] [12.] [13.] [14.] [15.] [16.], cardiovascular health [11.] [17.], cholesterol [2.] [14.] [15.] [18.] [19.] [20.] [21.], type 2 diabetes [3.] [22.] [23.] [24.], and obesity [12.] [17.] [22.] [23.] [24.] [25.] [26.]. 

The broad category of polyphenols is divided into four subgroups: flavonoids, lignans, phenolic acids, and stilbenes. [27.]  Multiple studies have demonstrated potential benefits (lower risk for coronary heart disease [28.] [29.] [30.] [31.], cardiovascular disease [29.] [31.], and stroke [32.] associated with regular consumption of dietary flavonoids. 

The polyphenol subgroup called flavonoids is further classified into six categories: flavones, flavanones, flavonols, flavanols, isoflavones, and anthocyanidins. [33.]  Flavanols are bioactive compounds derived from plants, teas, or cocoa [34.] [35.] that seem to have a positive effect on vascular / cardiovascular health and quality of life [36.] [37.].

 

Since Epi-Gro1000’s ingredients within the specific category of flavanols have demonstrated the ability to rapidly enhance vasodilation in peripheral arteries and improve endothelial function. [38.] [39.], it is easy to understand how individuals experience immediate physiological benefits.  While these physiological effects vary based on genetics, body size, and dosage, there may also be affected by interactions with other compounds or supplements.  For example, the methylxanthine known as caffeine seems to increase Epicatechin absorption and enhance its overall effects.  Since Epicatechin is the main ingredient of Epi-Gro1000 (1000 mg of Epicatechin per 2 capsules serving of Epi-Gro1000), consuming a serving of caffeine with a serving of Epi-Gro1000 may potentiate the effects.  In my opinion, this may be similar to the potentiating effect that caffeine has on aspirin. [40.] [41.]  However, consuming caffeine with Epi-Gro1000 is not mandatory to get the desired effects.

 

Throughout history studying indigenous people of specific regions has provided useful information to the nutrition and supplementation industry.  For example, in the 1970s, researchers studying the indigenous Greenland Eskimos discovered a potential link between omega-3 fatty acids (EPA and DHA) and heart health. [42.] [43.] [44.] [45.] [46.]  These initial investigations laid the foundation for thousands of clinical studies involving omega-3 fatty acids.

Another example involves Epi-Gro1000’s primary ingredient Epicatechin.  In the late 1990s, research teams discovered that Kuna Indians of the Caribbean Coast of Panama seemed to have a reduced frequency of cardiovascular disease and very low blood pressure [47.]  Since 24-hour food logs and urine collections indicated a sodium and chloride intake that exceeds most western populations [48.], researchers initially thought these individuals were genetically protected.  However, when researchers examined the Kuna Indians that migrated to urban areas, they found hypertension to be common and blood pressure to rise significantly with age.  The researchers quickly realized the observed cardiovascular health and blood pressure was environmental and not genetic.  Once the researchers performed a comprehensive dietary assessment, they found the hunter-gatherer island-dwelling Kuna consumed ~ 10 times more cocoa (~ 1880 mg of flavanols) per day than the urban-dwelling Kuna Indians. [47.] [49.]  Please do not misinterpret cocoa as chocolate.  Chocolate is a highly refined commercial product that typically lacks the important flavanol information on its label.  Cocoa or cacao is the fermented seed of Theobroma cacao tree.  In general, the raw unprocessed seed or bean contains the highest flavanol content.  Unfortunately, the flavanol content decreases as the seed or bean is refined and processed.  Since the Kuna prepare their cocoa drink in two steps (Step 1: grinding raw cacao beans, Step 2: boil ground cacao beans with a banana and strain the remaining solids prior to drinking), they consume significantly higher levels of flavanols than most.  A 2009 study estimated that the average cocoa consumption of the Kuna provides ~ 900 mg per day of the flavanol Epicatechin [50.]  If the main flavanol in cocoa is Epicatechin [51.] and clinical studies show that individuals receive the same nitric oxide and vasodilator response from Epicatechin and flavanol-rich cocoa [39.], then it may be the key mediator of cocoa’s beneficial effects.  In general, nitric oxide performs a multitude of biological functions and its bioactivity can be linked to numerous diseases. [52.]  If an individual is experiencing poor health from a lack of nitric oxide synthesis, then consuming a sufficient amount of the flavanol Epicatechin may provide a beneficial stimulus to the system.  In my opinion, if an individual becomes aware of this small slice of history on the flavanol Epicatechin, then they are more likely to appreciate its potential application and benefits.

 

One serving (2 capsules) of Epi-Gro1000 provides more Epicatechin (1000 mg) than the indigenous people of Kuna consumed in an entire day (~ 900 mg).  Therefore, if an individual wants to consume as much Epicatechin as the Kuna for the potential health promotion benefits, then one serving (2 capsules) of Epi-Gro1000 per day will satisfy the Epicatechin milligram requirements.

 

Question:

Does the main ingredient in Epi-Gro1000, Epicatechin, have any other potential benefits?

 

Answer:

Overall, multiple studies have provided mechanistic evidence for polyphenols à flavonoids à flavanols à Epicatechin’s potential health promotion or human performance effects.  For example:

  

Potential Human Performance Mechanisms or Effects

  • Increased Follistatin and Decreased Myostatin [53.]
  • Improved Skeletal Muscle Mitochondria (in Patients with Heart Failure and Type 2 Diabetes) [54.]
  • Increased Exercise Performance and Exercise Capacity [55.]
  • Improves Aerobic Metabolism Capacity and Skeletal Muscle Oxidative Capacity [55.]

 

Potential Health Promotion Mechanisms or Effects

  • Increased Endothelial Cell’s Nitric Oxide Production [56.]
  • Reduced Myocardial Injury [57.]
  • Unique Cardioprotective Effects of Sustained Long-Term Use (Reduced Myocardial Infarct Size, Reduced Epicardial Scar Stains, and Improved Left Ventricular Morphometry) [58.]
  • Cardioprotective through preservation of mitochondrial function [59.]
  • Cardioprotective through free radical scavenging and antioxidant effects [60.]

 

Question:

Does the secondary ingredient in Epi-Gro1000, Green Tea Extract 400 mg (50% EGCG = 200 mg), have similar benefits as well?

 

Answer:

In general, the categories of polyphenols à flavonoids à flavanols à Green Tea Extract (50% EGCG Catechins) have many potential health promotion and human performance properties.  In Epi-Gro1000, the secondary ingredient is generally referred to as Green Tea Extract.  More specifically, Swinney Nutrition’s formula uses a 50% EGCG extract of Catechins.  As mentioned above, a 50% EGCG extract of the 400 mg Green Tea Extract per 2 capsules serving provides 200 mg of EGCG Catechins per 2 capsules serving

 

 

 Question :

What is so special about 50% EGCG Catechins in Green Tea Extract?

 

 Answer :

EGCG, (-)-epigallocatechin-3-gallate, seems to be the most potent and studied bioactive ingredient in green tea.  Over the last thirty years, numerous clinical studies have associated green tea catechins with possible health promotion and human performance benefits.  For example:

 

  • Anti-cancer [61.] [62.] [63.] [64.] [65.] [66.] [67.] [68.] [69.] [70.] [71.] [72.]
  • Anti-Oxidant [73.]
  • Metal Chelating [74.] [75.]
  • Anti-Inflammatory [75.] [76.] [77.]
  • Anti-Microbial, Anti-Viral [78.] [79.] [80.]
  • Anti-Diabetic [81.] [82.]
  • Anti-Obesity [83.] [84.] [85.]
  • Neuroprotective [86.] [87.] [88.] [89.] [90.]

 

Question :

Understandably, there are numerous potential health promoting benefits of supplementing with Green Tea Extract, 50% EGCG.  In regard to human performance and body recomposition, how does this ingredient enhance an individual’s efforts?

 

 Answer :

This answer may vary slightly due to an individual’s genetics, training, nutrition, and supplementation protocols.  Beginning with the general information from animal models, green tea catechins demonstrated the potential to improve energy expenditure and fat metabolism. [91.] [92.] [93.]  Obviously, animals and humans are different, but acknowledging this information provides insight on the potential benefits of this ingredient.  In randomized controlled trails on obese humans, this ingredient improved weight loss and body recomposition. [94.] [95.] [96.] [97.] [98.]  In addition to the randomized controlled trials, two systematic reviews (2012 [99.] and 2017 [100.]) and one meta-analysis (2019 [101.]) support the potential fat loss benefits of green tea extract EGCG.  While green tea extract EGCG catechins may not work for all humans, the available clinical literature seems to suggest that it has the potential to help with fat loss.

 

Question :

While it seems obvious that this ingredient enhances fat loss, can Green Tea Extract, 50% EGCG also help with muscle growth?

 

 Answer :

While it has the potential to enhance specific mechanisms related to skeletal muscle hypertrophy, it is important to remember that individual responses can vary greatly, and context is key.  This ingredient may improve specific mechanisms related to skeletal muscle hypertrophy, but an individual needs to supply adequate protein (all 20 amino acids + auxiliary amino acids), complex carbohydrates (glucose à glycogen), medium chain triglyceride (C8 – Caprylic Acid, also known as CapTri Ò) and critically essential fatty acids (EPA, DHA, AA).  If an individual has checked all the nutritional boxes and training boxes for skeletal muscle growth, then they can consider how this specific ingredient may apply to their current training or nutrition protocol.

In my experience, the individuals that supplement with Epi-Gro1000 begins to develop skeletal muscle that appears rounder, fuller, thicker, and more cartoonish or bubbly.  While describing muscles as rounder, fuller, bubbly or cartoonish may sound weird, they seem to accurately describe my visual observation.  Then when Epi-Gro1000 was released to the public, I began to receive customer feedback (emails, text, and phone calls) describing a constant pumped, round, and full look to the skeletal muscles.  As mentioned earlier, Epi-Gro1000 contains 1000 mg of Epicatechin per 2 capsules serving and this ingredient is heavily linked to increased nitric oxide and blood flow, but there also seems to be a synergistic effect from the additional 400 mg of green tea extract (50% EGCG catechins).  In my opinion, this enhanced appearance may be linked to green tea extracts effect on glucose absorption and glycogen synthesis. 

 

In clinical studies, green tea extract catechins have demonstrated the ability to regulate glucose absorption via glucose transporter genes and insulin signaling pathways. [102.] [103.] [104.] [105.]  The overall effect of these molecular mechanisms is to increase the liver and skeletal muscle’s glucose uptake and glycogen storage.  If an individual’s skeletal muscle glycogen uptake is enhanced, then they will have the appearance described above.  Therefore, the combination of ingredients in Epi-Gro1000 synergistically enhances multiple aspects of body recomposition and appearance.

 

Question :

What is Huperzine A?

 

 Answer :

Huperzine A is a biologically active compound from the plant Huperzia serrata, referred to as “Qian Ceng Ta”, that has been used for centuries in Chinese Medicine. [106.] [107.] [108.]  This molecule seems to have the ability to penetrate the blood-brain-barrier and act as a reversible and selective acetylcholinesterase inhibitor. [109.] [110.] [111.] [112.] [113.] [114.]  Basically, this means that Huperzine A has the ability to increase levels of acetylcholine by preventing an enzyme from breaking down circulating acetylcholine.  Since acetylcholine is a neurotransmitter used in muscle contraction and learning, supplementing with Huperzine A may enhance available acetylcholine for training efforts.

 

Question :

Why is Huperzine A used in Epi-Gro1000?

 

 Answer :

Huperzine A is used in Epi-Gro1000 for multiple reasons.

Anecdotally, some physique enthusiasts have credited the synergistic combo of EGCG and Huperzine A with strengthening somatostatin inhibitors to their receptors and improving circulating growth hormone.  While this observation is purely anecdotal, individuals that use peptides like HGH (human growth hormone), GHRH (Growth Hormone Releasing Hormones), GHRP (Growth Hormone Releasing Peptides), GH oral (MK-677), and various other peptides (IGF-1, MGF, etc.) seem to quickly break through plateaus or stagnant periods of growth after the addition of Epi-Gro1000.  Understandably, it is nearly impossible to know if the results are from the combo of EGCG and Huperzine A strengthening somatostatin inhibition or the large dose of Epicatechin included in the Epi-Gro1000 formula.  In my experience, as long as an individual breaks through their current plateau or improves their overall body composition (without deleterious health effects), they don’t care if the results are from the exact dose of Epicatechin, EGCG, or Huperzine A, or the combo of all three ingredients.  

 

Unfortunately, the relationship between training and the central nervous system, peripheral nervous system, NGF (Nerve Growth Factors), skeletal muscle innervation potential, etc. is rarely discussed.  While these subjects may be rarely discussed, forming an understanding is highly beneficial for enhancing training performance and results (especially for the individuals using non-conventional or exotic supplements).  Huperzine A may not be considered non-conventional or exotic to some individuals, but some of the potential mechanisms may be outside of the traditional understanding or application of this ingredient.

As mentioned above, Huperzine A is a potent and selective acetylcholinesterase inhibitor that increases circulating levels of acetylcholine. 

  

Question :

What is the importance of Huperzine A inhibiting an enzyme that breaks down acetylcholine and increasing circulating acetylcholine?  Why does that matter for gaining muscle, losing body fat, or body recomposition?

 

 Answer :

While acetylcholine is rarely discussed in the fitness and physique industry, it is a critical neurotransmitter and neuromodulator that functions in the central nervous system and peripheral nervous system. 

 

Multiple clinical studies have demonstrated the potential for Huperzine A to improve cognitive function and delay cognitive disease (Alzheimer’s Disease and Dementia) through a multi-target mechanism (improving acetylcholine levels, attenuating oxidative stress, alleviating mitochondria dysfunction, etc.). [115.] [116.] [117.] [118.] [119.] [120.] [121.] [122.]  Since it seems to be neuroprotective and combat cognitive disease in aging or sick individuals, it may have the potential to enhance multiple cognitive functions in healthy individuals.  Initially, cognitive function may not be considered valuable to physique enhancement, but in my opinion, it should be.  If acetylcholine is involved in the process of learning and memory [123.], attention [124.], and alertness after waking [125.], then maintaining adequate levels is vital for staying focused, dedicated, and consistent on the periodized training and nutrition program.  If acetylcholine is able to promote deep rapid-eye movement (REM) sleep [126.] and improve wakefulness, then an individual is less likely to skip training due to lack of sleep, recovery, or arousal.  Additionally, individuals in pursuit of physique enhancement or body recomposition may greatly benefit from the neuroprotective mechanisms and neurotransmitter chemicals related to Huperzine A.

 

Describing the complex relationship between acetylcholine and the neuromuscular junction as it pertains to skeletal muscle activation-contraction may be too detailed and long winded for this question.  In an effort to keep the answer brief and concise as possible, acetylcholine’s role in the first few steps of muscle contraction will be described below:

(1st) The action potential triggers the motor neuron to release acetylcholine,

(2nd) the acetylcholine reaches the neuromuscular junction and initiates an electrochemical process

{acetylcholine binding to its receptor is critical for the transition of a chemical signal to electrical signal},

(3rd) the signal / impulse travels through the muscle fiber via the T-tubules,

(4th) the impulse causes the sarcoplasmic reticulum to release Ca+ ions,

{calcium ions play a pivotal role in initiating muscular contractions}...

Once the Ca+ ions bind with troponin (removing the blocking action of tropomyosin from actin binding sites) the myosin is ready to bind with actin to form cross bridges and begin the muscle contraction process. Next, ATP (energy) binds to myosin.  Then, ATP is hydrolyzed to ADP and Pi to provide the energy necessary to cock its head in the high-energy position. Finally, releasing ADP and Pi as they pull actin filaments inwards and return to low energy position.  If there is sufficient Ca+ ions and ATP, then the process can be repeated.

** Please understand that the description provided for a muscle contraction was simplified as much as possible to communicate the importance of acetylcholine.**

 

Acknowledging this process highlights the importance of acetylcholine in triggering a sequence of steps that generate a muscular contraction.  If a supplement increases the amount of acetylcholine available for a skeletal muscle contraction, then it may enhance the skeletal muscles contractile force.  However, another way to appreciate acetylcholine’s potential benefits is to examine individuals with lower levels of acetylcholine and acetylcholine receptors.  A systematic review on age associated sarcopenia (muscle loss) discovered a relationship between acetylcholine receptor degeneration and muscle loss. [127.]  Overall, the research on sarcopenia (age related muscle loss) and dynapenia (age related loss of muscle strength) is steadily improving and scientists are beginning to understand more about the effect of aging on the neuromuscular mechanisms associated with the progressive loss of muscle tissue and function. [128.] [129.] [130.] [131.]  Since the current landscape provides enough data to confirm a potential loss of acetylcholine with aging, it may be a good idea to consider methods for increasing circulating acetylcholine levels. 

 

The benefits of increasing acetylcholine levels is quite obvious for aging individuals, but it may also be beneficial for young healthy individuals as well.  In my experience, Epi-Gro1000’s benefits are not controlled by the age of the individual.  Anecdotally, I have witness individuals from the age of 18 to 80 get positive results from supplementing with Epi-Gro1000.  The results varied slightly per person.  In large, Epi-Gro1000 seemed to produce a body composition effect or plateau breaking effect. 

Example A: One of my 40-year-old clients had been stuck at roughly the same weight and body composition for a few months.  They decided to add 2 servings (2 capsules each) of Epi-Gro1000 per day for 3 months.  Once they came in for their body composition (Parrillo 9-site skin-fold test) assessment, the results showed a significant increase in muscle mass and decrease in fat mass. 

Example B: Another individual was trying to get lean enough to have a defined 6-pack (under 10% body fat, using Parrillo 9-site skin-fold test) and had been plateaued between 13% and 15% for over 6 months.  This individual decided to use 3 capsules of Epi-Gro1000 with their morning coffee, before their traditional 30-minute walk and another 3 capsules with lunch or in the afternoon.  This protocol provided immediate results and this individual was able to meet their goal in 8 weeks.  Since they didn’t make any changes to their nutrition program, I was impressed by their results.  While these results may be great, these examples are only the tip of the iceberg.

 

 Summary:

Hopefully this detailed summary and review of the ingredients in Epi-Gro1000 will provide beneficial information to the individuals reading it.  I will continue to update the information regarding the ingredients in Swinney Nutrition supplements.  Additionally, I will continue to add beneficial information about human physiology, nutrition, and training.  In my opinion, constantly studying the physiological, biological, and chemical processes in the human body is vital in understanding the potential application of quality supplements.  Combining the broad knowledge with specific interest may improve an individual’s ability to develop practical methods to achieve desired goals.


 

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